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Jorge Gandía, Víctor Fernández-Dueñas, Xavier Morató, Gianluigi Caltabiano, Rosario González-Muñiz, Leonardo Pardo, Igor Stagljar and Francisco Ciruela The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain Journal of Neurochemistry 125

Version of Record online: 3 MAR 2013 | DOI: 10.1111/jnc.12196

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GPR37 is a rather unknown orphan GPCR that in a genetic form of Parkinson's disease accumulates intracellularly and induces neuronal death. In this study, we describe a cystein-rich domain in the C-terminal tail of the receptor that controls its membrane expression and whose absence reduces the GPR37-dependent citotoxic effects on ER stress and cell death.

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