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Alicia J. Avelar, Steven A. Juliano and Paul A. Garris Amphetamine augments vesicular dopamine release in the dorsal and ventral striatum through different mechanisms Journal of Neurochemistry 125

Article first published online: 6 MAR 2013 | DOI: 10.1111/jnc.12197

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The psychostimulant amphetamine acts at multiple sites of dopamine neurotransmission. We found that amphetamine enhanced vesicular release in the dorsal striatum by activating synthesis and inhibiting degradation but targeting an alternative mechanism in the ventral striatum perhaps related to storage pools. Taken together, these results advance our understanding of region-specific cellular actions of amphetamine that mediate its potent behavior effects.

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