Can Chen, Yi Wang, Sally S. L. Goh, Jing Yang, Dang Hoang Lam, Yukti Choudhury, Felix Chang Tay, Shouhui Du, Wee Kiat Tan, Yovita Ida Purwanti, Weimin Fan and Shu Wang Inhibition of neuronal nitric oxide synthase activity promotes migration of human-induced pluripotent stem cell-derived neural stem cells toward cancer cells Journal of Neurochemistry 126
Version of Record online: 17 MAR 2013 | DOI: 10.1111/jnc.12199
Gene expression profiling revealed that expression of the gene encoding neuronal nitric oxide synthase (nNOS) was down-regulated in neural stem cells migrating toward tumor cells. Using nNOS inhibitors and nNOS siRNAs, we demonstrated that nNOS is a relevant regulator in controlling tumor tropism of neural stem cells. This finding suggests a novel application of nNOS inhibitors in neural stem cell-mediated cancer therapy.
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