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Danielle M. Friend and Kristen A. Keefe Glial reactivity in resistance to methamphetamine-induced neurotoxicity Journal of Neurochemistry 125

Version of Record online: 17 MAR 2013 | DOI: 10.1111/jnc.12201

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We examined astrocyte and microglial reactivity in animals experiencing methamphetamine toxicity and in animals resistant to such toxicity. Animals experiencing toxicity showed activated microglia, whereas animals resistant to toxicity did not. Additionally, GFAP expression was similar whether an animal was experiencing toxicity or not, suggesting that astrocyte reactivity does not reflect acute METH-induced dopamine toxicity, whereas microglial reactivity does. DL, dorsolateral striatum; black bars: DM, dorsomedial striatum; white bars.

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