E-mail

E-mail a Wiley Online Library Link

Lei Gu and Zhefeng Guo Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils Journal of Neurochemistry 126

Article first published online: 12 MAR 2013 | DOI: 10.1111/jnc.12202

Thumbnail image of graphical abstract

Amyloid plaques in Alzheimer's brains consist of mostly Aβ42, and some plaques contain only Aβ42, even though Aβ40 is several-fold more concentrated than Aβ42. Here, we show that a mixture of Aβ42 and Aβ40 forms interlaced fibrils in vitro, seemingly contradicting in vivo observations. We propose some potential mechanisms that may contribute to the preferential deposition of Aβ42 in Alzheimer's.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH