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Lei Gu and Zhefeng Guo Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils Journal of Neurochemistry 126

Version of Record online: 12 MAR 2013 | DOI: 10.1111/jnc.12202

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Amyloid plaques in Alzheimer's brains consist of mostly Aβ42, and some plaques contain only Aβ42, even though Aβ40 is several-fold more concentrated than Aβ42. Here, we show that a mixture of Aβ42 and Aβ40 forms interlaced fibrils in vitro, seemingly contradicting in vivo observations. We propose some potential mechanisms that may contribute to the preferential deposition of Aβ42 in Alzheimer's.

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