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Kate M. Candelario, C. William Shuttleworth and Lee Anna Cunningham Neural stem/progenitor cells display a low requirement for oxidative metabolism independent of hypoxia inducible factor-1alpha expression Journal of Neurochemistry 125

Article first published online: 11 MAR 2013 | DOI: 10.1111/jnc.12204

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Neural stem/progenitor cells (NSPCs) preferentially rely on glycolysis and the pentose phosphate pathway (PPP) for survival, and maintain a low requirement for mitochondrial oxidative phosphorylation. Glycolytic dependence under aerobic conditions has been linked to HIF-1α in certain cancer cell types; however, inducible gene deletion of Hif1a did not shift metabolic phenotype or render cultured murine NSPCs susceptible to hypoxia.

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