Rachel A. Hill, Yee-Wen Candace Wu, Andrea Gogos and Maarten van den Buuse Sex-dependent alterations in BDNF-TrkB signaling in the hippocampus of reelin heterozygous mice: a role for sex steroid hormones Journal of Neurochemistry 126
Reduced expression of both Reelin and Brain-Derived Neurotrophic factor (BDNF) genes has been associated with schizophrenia in human post-mortem studies. We report a female-specific interaction between these two genes in a specific region of the hippocampus in mice, and this was mediated by estradiol. These data provide a better understanding of the sex-specific pathogenesis of schizophrenia.
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