Marie-Josèphe Salles, Denis Hervé, Jean-Michel Rivet, Sophie Longueville, Mark J. Millan, Jean–Antoine Girault and Clotilde Mannoury la Cour Transient and rapid activation of Akt/GSK-3β and mTORC1 signaling by D3 dopamine receptor stimulation in dorsal striatum and nucleus accumbens Journal of Neurochemistry 125
Stimulation of D3, and possibly D2, dopamine receptors transiently activates Akt in the medium-size spiny neurons of the dorsal striatum and nucleus accumbens. Activated Akt can phosphorylate GSK-3β and, indirectly, several effectors of mTORC1: p70S6 kinase (p70S6K), ribosomal protein-S6 (rpS6), and eukaryotic initiation factor-4E binding protein-1 (4E-BP1). These pathways may underpin the actions of D3 receptors on diverse cerebral functions.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf