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Marie-Josèphe Salles, Denis Hervé, Jean-Michel Rivet, Sophie Longueville, Mark J. Millan, Jean–Antoine Girault and Clotilde Mannoury la Cour Transient and rapid activation of Akt/GSK-3β and mTORC1 signaling by D3 dopamine receptor stimulation in dorsal striatum and nucleus accumbens Journal of Neurochemistry 125

Version of Record online: 11 MAR 2013 | DOI: 10.1111/jnc.12206

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Stimulation of D3, and possibly D2, dopamine receptors transiently activates Akt in the medium-size spiny neurons of the dorsal striatum and nucleus accumbens. Activated Akt can phosphorylate GSK-3β and, indirectly, several effectors of mTORC1: p70S6 kinase (p70S6K), ribosomal protein-S6 (rpS6), and eukaryotic initiation factor-4E binding protein-1 (4E-BP1). These pathways may underpin the actions of D3 receptors on diverse cerebral functions.

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