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Balu Chakravarthy, Michel Ménard, Leslie Brown, Melissa Hewitt, Trevor Atkinson and James Whitfield A synthetic peptide corresponding to a region of the human pericentriolar material 1 (PCM-1) protein binds β-amyloid (Aβ1-42) oligomers Journal of Neurochemistry 126

Article first published online: 18 MAR 2013 | DOI: 10.1111/jnc.12208

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We have synthesized a ~ 5 kDa Aβ binding peptide (ABP-p-4-5), a derivative of the human pericentriolar material-1 protein that is involved in cell cycle transit and neurogenesis. ABP-p-4-5 selectively binds with high affinity Aβ1-42 oligomers that are believed to be the toxic drivers of AD (Alzheimer's disease). These observations suggest that ABP-p-4-5 peptide may prove to be an AD therapeutic.

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