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Francesca Boscia, Carla Lucia Esposito, Antonella Casamassa, Vittorio de Franciscis, Lucio Annunziato and Laura Cerchia The isolectin IB4 binds RET receptor tyrosine kinase in microglia Journal of Neurochemistry 126

Version of Record online: 17 MAR 2013 | DOI: 10.1111/jnc.12209

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The study demonstrates that isolectin IB4, commonly used as a microglial marker in the brain, binds to the glycosylated ectodomain of Ret tyrosine kinase receptor, the signaling component for the family ligands of the glial cell line-derived neurotrophic factor. Binding was observed in microglia under physiological and ischemic conditions, thus indicating Ret as one of the IB4-reactive glycoconjugate accounting for the IB4 stain in microglia.

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