E-mail

E-mail a Wiley Online Library Link

Francesca Boscia, Carla Lucia Esposito, Antonella Casamassa, Vittorio de Franciscis, Lucio Annunziato and Laura Cerchia The isolectin IB4 binds RET receptor tyrosine kinase in microglia Journal of Neurochemistry 126

Article first published online: 17 MAR 2013 | DOI: 10.1111/jnc.12209

Thumbnail image of graphical abstract

The study demonstrates that isolectin IB4, commonly used as a microglial marker in the brain, binds to the glycosylated ectodomain of Ret tyrosine kinase receptor, the signaling component for the family ligands of the glial cell line-derived neurotrophic factor. Binding was observed in microglia under physiological and ischemic conditions, thus indicating Ret as one of the IB4-reactive glycoconjugate accounting for the IB4 stain in microglia.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH