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Ursula Hartmann, Hanni Hülsmann, Judith Seul, Sandra Röll, Heven Midani, Isabelle Breloy, Daniel Hechler, Regina Müller and Mats Paulsson Testican-3: a brain-specific proteoglycan member of the BM-40/SPARC/osteonectin family Journal of Neurochemistry 125

Article first published online: 12 MAR 2013 | DOI: 10.1111/jnc.12212

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The testicans are a three-member family of secreted proteoglycans structurally related to the BM-40/SPARC/osteonectin family of extracellular calcium-binding proteins. Here, we describe the biochemical characterization and tissue distribution of mouse testican-3 as well as the inactivation of the corresponding gene. Native testican-3 is a neuronal heparan sulphate (HS) proteoglycan located diffusely within the brain extracellular matrix as well as associated with cells. Mice deficient in testican-3 are viable and fertile and do not show an obvious phenotype. TCAN, testican-specific domain I; FS, follistatin-like domain; EC, extracellular calcium-binding domain; TY, thyroglobulin-like domain; V, C-terminal domain V; HS, heparan sulphate; WT, wildtype; KO, knockout; w, weeks after birth; E, embryonic day.

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