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Koro Gotoh, Takayuki Masaki, Seiichi Chiba, Hisae Ando, Kansuke Fujiwara, Takanobu Shimasaki, Kimihiko Mitsutomi, Isao Katsuragi, Tetsuya Kakuma, Toshiie Sakata and Hironobu Yoshimatsu Brain-derived neurotrophic factor, corticotropin-releasing factor, and hypothalamic neuronal histamine interact to regulate feeding behavior Journal of Neurochemistry 125

Version of Record online: 19 MAR 2013 | DOI: 10.1111/jnc.12213

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We have developed a working model of neuronal network via signaling between brain-derived neurotrophic factor (BDNF) and neuronal histamine. BDNF may act on histamine neurons in in the tuberomammillary nucleus (TMN) through corticotropin-releasing factor (CRF) neurons in the paraventricular nucleus (PVN). Furthermore, neuronal histamine also stimulates BDNF neurons in the ventromedial nucleus (VMH) directly.

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