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Wha Y. Kim, Ju K. Jang, Jung W. Lee, Hyunduk Jang and Jeong-Hoon Kim Decrease of GSK3β phosphorylation in the rat nucleus accumbens core enhances cocaine-induced hyper-locomotor activity Journal of Neurochemistry 125

Version of Record online: 24 MAR 2013 | DOI: 10.1111/jnc.12222

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The increased phosphorylation levels for GSK3β in the nucleus accumbens (NAcc) have known to attenuate psychomotor stimulants-induced hyperactivity. However, the opposite direction has not been studied. Here we found that decreased levels of GSK3β phosphorylation in the NAcc core enhance cocaine-induced hyper-locomotor activity. This is the first demonstration that the selective decrease of GSK3β phosphorylation levels actually contributes positively to cocaine-induced locomotor activity.

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