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Hidekazu Sotoyama, Hisaaki Namba, Satomi Chiken, Atsushi Nambu and Hiroyuki Nawa Exposure to the cytokine EGF leads to abnormal hyperactivity of pallidal GABA neurons: implications for schizophrenia and its modeling Journal of Neurochemistry 126

Article first published online: 25 MAR 2013 | DOI: 10.1111/jnc.12223

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Pallidal hyperactivity and hyperdopaminergic states found in a cytokine model for schizophrenia

The indirect pathway of the basal ganglia circuit is implicated in cognition, motor coordination, learning and antipsychotic pharmacology. The activity of globus pallidus neurons in this pathway is markedly modulated by dopaminergic afferents. Perinatal expose to EGF induces pallidal hyperdopaminergic innervation and elevates their firing rates, resulting in increased GABA release. This pallidal dysfunction contributes to the neurobehavioral deficits of this animal model for schizophrenia.

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