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Chiung-Chun Huang, Che-Ming Yeh, Mei-Ying Wu and Kuei-Sen Hsu A single in vivo cocaine administration impairs 5-HT1B receptor-induced long-term depression in the nucleus accumbens Journal of Neurochemistry 125

Article first published online: 19 MAR 2013 | DOI: 10.1111/jnc.12227

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We investigate whether dysregulation of serotonergic modulation of glutamatergic transmission in the NAc would have a significant role in the development of cocaine addiction. We find that a single in vivo exposure to cocaine impairs the induction of 5-HT-LTD in the NAc. It provides major advances in our understanding of the functional role of the 5-HT system in the NAc.

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