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Lyle Wiemerslage, Bradley J. Schultz, Archan Ganguly and Daewoo Lee Selective degeneration of dopaminergic neurons by MPP+ and its rescue by D2 autoreceptors in Drosophila primary culture Journal of Neurochemistry 126

Version of Record online: 24 MAR 2013 | DOI: 10.1111/jnc.12228

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This study showed that a PD toxin MPP+ causes selective degeneration of dopaminergic (DA) neurons in a Drosophila primary culture. We also found that MPP+-mediated neurodegeneration was rescued by D2 agonists. Furthermore, activation of Drosophila D2 autoreceptors (D2Rauto) prevents MPP+ toxicity through suppression of DA neuronal excitability (or excitotoxicity).

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