Rong Chen, Conor P. Daining, Haiguo Sun, Rheaclare Fraser, Stephanie L. Stokes, Michael Leitges and Margaret E. Gnegy Protein kinase Cβ is a modulator of the dopamine D2 autoreceptor-activated trafficking of the dopamine transporter Journal of Neurochemistry 125
We proposed that increased dopamine transporter membrane insertion upon activation of dopamine D2 autoreceptor is because of enhanced recycling of the transporter. This trafficking is modulated by the PKCβ - ERK signaling cascade with PKCβ upstream of ERK. Our findings suggest PKCβ as a new potential target for treatment of diseases with dysfunctional presynaptic dopaminergic transmission.
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