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Rong Chen, Conor P. Daining, Haiguo Sun, Rheaclare Fraser, Stephanie L. Stokes, Michael Leitges and Margaret E. Gnegy Protein kinase Cβ is a modulator of the dopamine D2 autoreceptor-activated trafficking of the dopamine transporter Journal of Neurochemistry 125

Article first published online: 18 MAR 2013 | DOI: 10.1111/jnc.12229

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We proposed that increased dopamine transporter membrane insertion upon activation of dopamine D2 autoreceptor is because of enhanced recycling of the transporter. This trafficking is modulated by the PKCβ - ERK signaling cascade with PKCβ upstream of ERK. Our findings suggest PKCβ as a new potential target for treatment of diseases with dysfunctional presynaptic dopaminergic transmission.

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