Minghui Tan, Shanshan Ma, Qiaoying Huang, Kunhua Hu, Bin Song and Mingtao Li GSK-3α/β-mediated phosphorylation of CRMP-2 regulates activity-dependent dendritic growth Journal of Neurochemistry 125
Neuronal activity is critical for dendritic growth. We found that both GSK-3α and GSK-3β are involved in regulating activity-dependent dendritic growth. Neuronal activity inactivates GSK-3α/β via phosphorylation on Ser21/9, leading to the activation of their downstream effector CRMP-2, thus promoting dendritic growth. These findings identify a novel role for GSK-3/CRMP-2 pathway in connecting neuronal activity to dendritic growth.
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