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Shannon Levesque, Thomas Taetzsch, Melinda E. Lull, Jo Anne Johnson, Constance McGraw and Michelle L. Block The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function Journal of Neurochemistry 125

Version of Record online: 2 APR 2013 | DOI: 10.1111/jnc.12231

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Diesel exhaust particles (DEP) are a major component of urban air pollution, which has been linked to microglial activation and Parkinson's disease-like pathology. Urban particulate matter is reported to reach the brain, but how microglia identify and respond to DEP is poorly understood. These findings reveal that pattern recognition receptors are key to the microglial response to DEP, where scavenger receptors regulate the internalization and MAC1 mediates ROS production and loss of DA neuron function.

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