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Christopher D. Howard, Elissa D. Pastuzyn, Melissa L. Barker-Haliski, Paul A. Garris and Kristen A. Keefe Phasic-like stimulation of the medial forebrain bundle augments striatal gene expression despite methamphetamine-induced partial dopamine denervation Journal of Neurochemistry 125

Article first published online: 1 APR 2013 | DOI: 10.1111/jnc.12234

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Methamphetamine (METH) neurotoxicity decreases striatal dopamine content. Associated with this dopamine depletion are deficits in phasic DA signaling, which is important for reward-based learning, and dysregulation of striatal gene expression. Here, using electrical stimulation of the medial forebrain bundle to activate dopamine neurons, we show that augmenting phasic DA signaling normalizes striatal gene expression, despite METH-induced partial DA depletions.

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