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Sharmilee Gnanapavan, Peggy Ho, Wendy Heywood, Sam Jackson, Donna Grant, Khadija Rantell, Geoff Keir, Kevin Mills, Lawrence Steinman and Gavin Giovannoni Progression in multiple sclerosis is associated with low endogenous NCAM Journal of Neurochemistry 125

Version of Record online: 19 APR 2013 | DOI: 10.1111/jnc.12236

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We provide in-vitro and in-vivo evidence that NCAM is adversely affected by demyelination and is steadily depleted through CIS, RRMS and SPMS. We think that reduction in NCAM is one of the factors associated with or possibly responsible for the progression of MS.

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