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Mikaela Nichkova, Paul M. Wynveen, David T. Marc, Han Huisman and Gottfried H. Kellermann Validation of an ELISA for urinary dopamine: applications in monitoring treatment of dopamine-related disorders Journal of Neurochemistry 125

Version of Record online: 25 APR 2013 | DOI: 10.1111/jnc.12248

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Our competitive ELISA for direct dopamine quantification in urine samples is a viable cost-effective alternative to chromatographic analysis. The method is robust, sensitive, and very specific and it does not require sample pre-treatment. It can be used in monitoring dopamine-modulating therapies. Urinary dopamine levels significantly increase in a dose-dependent manner for Parkinson's disease patients under l-DOPA treatment.

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