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Carina Halleskog and Gunnar Schulte WNT-3A and WNT-5A counteract lipopolysaccharide-induced pro-inflammatory changes in mouse primary microglia Journal of Neurochemistry 125

Article first published online: 22 APR 2013 | DOI: 10.1111/jnc.12250

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WNTs are lipoglycoproteins, which affect microglia, the macrophages of the CNS, in a pro-inflammatory manner. Here, we show for the first time that WNTs in co-stimulation with lipopolysaccharides, however, reduce the lipopolysaccharide-induced pro-inflammatory effects e g on cyclooxygenase expression. Based on our findings we suggest that WNTs act as homeostatic regulators acting pro- or anti-inflammatory in a context-dependent manner.

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