Troy S. Peterson, Christina N. Thebeau, Deepa Ajit, Jean M. Camden, Lucas T. Woods, W. Gibson Wood, Michael J. Petris, Grace Y. Sun, Laurie Erb and Gary A. Weisman Up-regulation and activation of the P2Y2 nucleotide receptor mediate neurite extension in IL-1β-treated mouse primary cortical neurons Journal of Neurochemistry 125
Inflammation is a characteristic of Alzheimer's disease. The P2Y2 protein receptor has been found to be upregulated under inflammatory conditions. Activation of the receptor by UTP promotes interactions with αvβ3/5 integrin and signals G12-dependent Rho activation leading to cofilin phosphorylation involved in neurite extension. This study indicates that up-regulation of P2Y2Rs in mouse primary cortical neurons under pro-inflammatory conditions can promote cofilin-dependent neurite outgrowth, a neuroprotective response that may be a novel pharmacological target in the treatment of neurodegenerative diseases.
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