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Silvia Ravera, Lucilla Nobbio, Davide Visigalli, Martina Bartolucci, Daniela Calzia, Fulvia Fiorese, Gianluigi Mancardi, Angelo Schenone, Alessandro Morelli and Isabella Panfoli Oxydative phosphorylation in sciatic nerve myelin and its impairment in a model of dysmyelinating peripheral neuropathy Journal of Neurochemistry 126

Article first published online: 30 APR 2013 | DOI: 10.1111/jnc.12253

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The article describes the functionality of an extramitochondrial oxidative phosphorylation (OXPHOS) in peripheral (sciatic) nerve. Isolated myelin vesicles express functional respiratory complexes and produce ATP, consuming oxygen. This ability is impaired when myelin is isolated from dys/demyelinated (CMT1A) sciatic nerve, although the OXPHOS proteins are present. This suggests that myelin structure is fundamental for the activity of the respiratory complexes.

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