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Mohammad A. Rashid, Masanori Katakura, Giorgi Kharebava, Karl Kevala and Hee-Yong Kim N-docosahexaenoylethanolamine is a potent neurogenic factor for neural stem cell differentiation Journal of Neurochemistry 125

Article first published online: 13 MAY 2013 | DOI: 10.1111/jnc.12255

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Neural stem cells (NSCs) produce synaptamide (N-docosahexaenoylethanolamine) from docosahexaenoic acid (DHA). Synaptamide potently induces neuronal differentiation of NSCs through PKA-CREB signaling. The neurogenic capacity of NSCs is linked to the endogenous synaptamide level which depends on synaptamide stability and DHA availability in NSCs. Dietary omega-3 fatty acid intake that influences endogenous DHA and synaptamide levels may have significant impact on neurodevelopment.

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