Masahiro Shibasaki, Daiki Masukawa, Kazunori Ishii, Yui Yamagishi, Tomohisa Mori and Tsutomu Suzuki Involvement of the K+-Cl− co-transporter KCC2 in the sensitization to morphine-induced hyperlocomotion under chronic treatment with zolpidem in the mesolimbic system Journal of Neurochemistry 125
We found that chronic treatment with benzodiazepines enhanced morphine-induced hyperlocomotion through the increase of KCC2 in the nucleus accumbens. Furthermore, phosphorylation of protein kinase C γ (PKCγ induced the up-regulation of KCC2 through inactivation of protein phosphatase-1 (PP-1). These findings indicate that chronic treatment with benzodiazepines enhances dopaminergic signal transduction as a post-synaptic event.
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