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Michiko Nakamura, Kyungho Suk, Maan-Gee Lee and Il-Sung Jang α2A adrenoceptor-mediated presynaptic inhibition of GABAergic transmission in rat tuberomammillary nucleus neurons Journal of Neurochemistry 125

Article first published online: 25 APR 2013 | DOI: 10.1111/jnc.12259

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Histaminergic neurons in the tuberomammillary nucleus (TMN) play an important role in the regulation of sleep-wakefulness. In this study, we found that norepinephrine acts on presynaptic α2A adrenoceptors to inhibit GABAergic transmission onto TMN neurons. This α2A adrenoceptor-mediated presynaptic modulation may affect the excitability of TMN neurons and thus contribute to the behavioral state-dependent consolidation of wakefulness.

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