Michiko Nakamura, Kyungho Suk, Maan-Gee Lee and Il-Sung Jang α2A adrenoceptor-mediated presynaptic inhibition of GABAergic transmission in rat tuberomammillary nucleus neurons Journal of Neurochemistry 125
Histaminergic neurons in the tuberomammillary nucleus (TMN) play an important role in the regulation of sleep-wakefulness. In this study, we found that norepinephrine acts on presynaptic α2A adrenoceptors to inhibit GABAergic transmission onto TMN neurons. This α2A adrenoceptor-mediated presynaptic modulation may affect the excitability of TMN neurons and thus contribute to the behavioral state-dependent consolidation of wakefulness.
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