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Sebok K. Halder, Hayato Matsunaga, Ken J. Ishii, Shizuo Akira, Kensuke Miyake and Hiroshi Ueda Retinal cell type-specific prevention of ischemia-induced damages by LPS-TLR4 signaling through microglia Journal of Neurochemistry 126

Article first published online: 13 MAY 2013 | DOI: 10.1111/jnc.12262

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We proposed the following mechanism for LPS preconditioning-induced retinal prevention against ischemia: LPS preconditioning-induced retinal prevention against ischemic damages is mediated by toll-like receptor (TLR4) signaling through microglia. This TLR4 priming by LPS preconditioning dominantly activates TRIF-IRF3 (TIR-domain-containing adapter-inducing interferon-β/interferon regulatory factor 3) pathway and suppresses MyD88 - NF-κB pathway. Thus, detailed study of these findings may provide novel idea for discovery of new drugs against ischemic disorders.

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