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Ling Ye, Yunlong Huang, Lixia Zhao, Yuju Li, Lijun Sun, You Zhou, Guanxiang Qian and Jialin C. Zheng IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase Journal of Neurochemistry 125

Version of Record online: 3 MAY 2013 | DOI: 10.1111/jnc.12263

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Pro-inflammatory cytokines such as TNF-α and IL-1β increase kidney-type mitochondrial glutaminase in the cytosol of neurons and TNF-α may further release glutaminase to the extracellular space. Consequently, intracellular and extracellular glutamate levels increase in neurons during inflammation. The excess levels of glutamate in the extracellular space may induce neuronal injury and death. Therefore, neuronal glutaminase is a potential component of neurotoxicity during inflammation.

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