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Du-Hyong Cho, Eun Joo Lee, Kyoung Ja Kwon, Chan Young Shin, Kee-Ho Song, Jung-Hyun Park, Inho Jo and Seol-Heui Han Troglitazone, a thiazolidinedione, decreases tau phosphorylation through the inhibition of cyclin-dependent kinase 5 activity in SH-SY5Y neuroblastoma cells and primary neurons Journal of Neurochemistry 126

Version of Record online: 15 MAY 2013 | DOI: 10.1111/jnc.12264

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Thiazolidinediones (TZDs) decrease tau-Thr231 phosphorylation via the inhibition of CDK5 enzymatic activity, which is mediated by the enhanced proteasomal degradation of p35 and a PPARγ-independent signaling pathway. This molecular mechanism implies a role for TZD drugs in the prevention and treatment of Alzheimer's disease.

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