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Soonmoon Yoo, Hak H. Kim, Paul Kim, Christopher J. Donnelly, Ashley L. Kalinski, Deepika Vuppalanchi, Michael Park, Seung J. Lee, Tanuja T. Merianda, Nora I. Perrone-Bizzozero and Jeffery L. Twiss A HuD-ZBP1 ribonucleoprotein complex localizes GAP-43 mRNA into axons through its 3′ untranslated region AU-rich regulatory element Journal of Neurochemistry 126

Article first published online: 30 APR 2013 | DOI: 10.1111/jnc.12266

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We have recently found that over-expression of GAP-43 using an axonally targeted construct with the 3′UTRs of GAP-43 promoted elongating growth of axons, while restricting the mRNA to the cell body with the 3′UTR of γ-actin had minimal effect on axon length. In this study, we show that the ARE in GAP-43′s 3′UTR is responsible for localization of GAP-43 mRNA into axons and is sufficient for GAP-43 protein's role in elongating axonal growth.

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