Yelena Y. Grinberg, Megan E. Dibbern, Victoria A. Levasseur and Richard P. Kraig Insulin-like growth factor-1 abrogates microglial oxidative stress and TNF-α responses to spreading depression Journal of Neurochemistry 126
Spreading depression (SD), the likely cause of migraine, occurs with increased TNF-α and oxidative stress (OS), which we show is specific to microglia and astrocytes. We then show TNF-α and SD itself increase susceptibility to subsequent SD. IGF-1 decreases TNF-α and microglial OS from SD. These findings support IGF-1 and microglial OS as potential therapeutic targets against SD and perhaps migraine.
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