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Yelena Y. Grinberg, Megan E. Dibbern, Victoria A. Levasseur and Richard P. Kraig Insulin-like growth factor-1 abrogates microglial oxidative stress and TNF-α responses to spreading depression Journal of Neurochemistry 126

Version of Record online: 30 APR 2013 | DOI: 10.1111/jnc.12267

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Spreading depression (SD), the likely cause of migraine, occurs with increased TNF-α and oxidative stress (OS), which we show is specific to microglia and astrocytes. We then show TNF-α and SD itself increase susceptibility to subsequent SD. IGF-1 decreases TNF-α and microglial OS from SD. These findings support IGF-1 and microglial OS as potential therapeutic targets against SD and perhaps migraine.

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