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Ya Meng, Yue Yong, Guang Yang, Hanqing Ding, Zhiqin Fan, Yifen Tang, Jia Luo and Zun-Ji Ke Autophagy alleviates neurodegeneration caused by mild impairment of oxidative metabolism Journal of Neurochemistry 126

Version of Record online: 9 JUN 2013 | DOI: 10.1111/jnc.12268

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Autophagy is neuroprotective in response to thiamine deficiency (TD)-induced neuronal death. TD caused neuronal damage and induced the formation of autophagosome, and increased the expression of autophagy-related proteins. Autophagy sequestered damaged and dysfunctional organelles/protein, and transported them to lysosomes for degradation/recycling. This process provided nutrients for injured neurons. Wortmannin and knockdown of Beclin1 inhibited autophagy, and exacerbated TD-induced cell death, while activation of autophagy by rapamycin offered protection against TD neurotoxicity.

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