Olivia Hurtado, Macarena Hernández-Jiménez, Juan G. Zarruk, María I. Cuartero, Iván Ballesteros, Guadalupe Camarero, Ana Moraga, Jesús M. Pradillo, María A. Moro and Ignacio Lizasoain Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke Journal of Neurochemistry 126
Sirtuin 1 (SIRT1) is implicated in a wide range of cellular functions. Regarding stroke, there is no direct evidence. We have demonstrated that citicoline increases SIRT1 protein levels in brain concomitantly to neuroprotection. Citicoline fails to reduce infarct volume in Sirt1-/- mice. Our findings suggest that therapeutic strategies acting on SIRT1 may be useful in the treatment of stroke.
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