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Aswini Gnanasekaran, Mayya Sundukova, Swathi Hullugundi, Nicol Birsa, Giorgio Bianchini, Yi-Ping Hsueh, Andrea Nistri and Elsa Fabbretti Calcium/calmodulin-dependent serine protein kinase (CASK) is a new intracellular modulator of P2X3 receptors Journal of Neurochemistry 126

Version of Record online: 13 MAY 2013 | DOI: 10.1111/jnc.12272

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ATP-gated P2X3 receptors are important transducers of painful stimuli. This study investigated the role of calcium/calmodulin-dependent serine protein kinase (CASK) in interacting and controlling P2X3 receptor expression and function in sensory ganglion neurons. As CASK-mediated control of P2X3 receptors was dependent on the receptor activation state, CASK might be an intracellular gateway to regulate purinergic nociceptive signaling.

Read the Editorial Highlight for this article on doi: 10.1111/jnc.12282.

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