Aswini Gnanasekaran, Mayya Sundukova, Swathi Hullugundi, Nicol Birsa, Giorgio Bianchini, Yi-Ping Hsueh, Andrea Nistri and Elsa Fabbretti Calcium/calmodulin-dependent serine protein kinase (CASK) is a new intracellular modulator of P2X3 receptors Journal of Neurochemistry 126
ATP-gated P2X3 receptors are important transducers of painful stimuli. This study investigated the role of calcium/calmodulin-dependent serine protein kinase (CASK) in interacting and controlling P2X3 receptor expression and function in sensory ganglion neurons. As CASK-mediated control of P2X3 receptors was dependent on the receptor activation state, CASK might be an intracellular gateway to regulate purinergic nociceptive signaling.
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