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Maria Giuseppina Pisu, Anna Garau, Pierluigi Olla, Francesca Biggio, Cinzia Utzeri, Riccardo Dore and Mariangela Serra Altered stress responsiveness and hypothalamic-pituitary-adrenal axis function in male rat offspring of socially isolated parents Journal of Neurochemistry 126

Article first published online: 9 MAY 2013 | DOI: 10.1111/jnc.12273

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Adult offspring of isolated rats exhibited an increased brain level of allopregnanolone, increased basal activity of the HPA axis, reduction of hypothalamic CRF and CRFR1 in the pituitary. There was also attenuation of corticosterone response by acute stress and up-regulation of GR expression in the hippocampus. In conclusion, a stressful experience before mating influence neuroendocrine signalling in the next generation.

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