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Indrek Saar, Jaanus Lahe, Kent Langel, Johan Runesson, Kristin Webling, Jaak Järv, Jussi Rytkönen, Ale Närvänen, Tamas Bartfai, Kaido Kurrikoff and Ülo Langel Novel systemically active galanin receptor 2 ligands in depression-like behavior Journal of Neurochemistry 127

Version of Record online: 31 MAY 2013 | DOI: 10.1111/jnc.12274

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We utilize several chemical modifications to increase in vivo usability of peptide-based ligands, acting upon CNS. Accordingly, we introduce a series of novel systemically active galanin analogues, with modest preferential binding towards GalR2, and demonstrate their ability to attenuate depression-like behavior via brain GalR2 in different mouse models of depression.

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