E-mail a Wiley Online Library Link

Indrek Saar, Jaanus Lahe, Kent Langel, Johan Runesson, Kristin Webling, Jaak Järv, Jussi Rytkönen, Ale Närvänen, Tamas Bartfai, Kaido Kurrikoff and Ülo Langel Novel systemically active galanin receptor 2 ligands in depression-like behavior Journal of Neurochemistry 127

Version of Record online: 31 MAY 2013 | DOI: 10.1111/jnc.12274

Thumbnail image of graphical abstract

We utilize several chemical modifications to increase in vivo usability of peptide-based ligands, acting upon CNS. Accordingly, we introduce a series of novel systemically active galanin analogues, with modest preferential binding towards GalR2, and demonstrate their ability to attenuate depression-like behavior via brain GalR2 in different mouse models of depression.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field