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Akihiro Matsuda, Kohjiro Nagao, Michinori Matsuo, Noriyuki Kioka and Kazumitsu Ueda 24(S)-hydroxycholesterol is actively eliminated from neuronal cells by ABCA1 Journal of Neurochemistry 126

Version of Record online: 8 MAY 2013 | DOI: 10.1111/jnc.12275

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ABCA1 actively eliminates 24-OHC in the presence of HDL and protects neuronal cells from apoptosis. High cholesterol turnover is essential for neural functions and 24(S)-hydroxycholesterol (24-OHC) is the major cholesterol metabolite in the brain. However, 24-OHC is toxic to neuronal cells. We propose that two ABC proteins, ABCA1 and ABCG1, are involved in active elimination of 24-OHC in the presence of HDL as a lipid acceptor and protect neuronal cells from apoptosis.

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