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Sara Fernandez-Lizarbe, Jorge Montesinos and Consuelo Guerri Ethanol induces TLR4/TLR2 association, triggering an inflammatory response in microglial cells Journal of Neurochemistry 126

Version of Record online: 8 MAY 2013 | DOI: 10.1111/jnc.12276

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We have shown that ethanol promotes TLR4 activation through its interactions with the lipid rafts microdomains. Here, we report that ethanol triggers TLR4/TLR2 recruitment into microglia lipid rafts/caveolae, promoting TLR4 and TLR2 interactions and signaling and leading to the production of proinflammatory cytokines, which cause ROS generation and neuronal apoptosis. These findings might provide a mechanism for alcohol-triggered neuroinflammation and brain damage.

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