Bénédicte Rossi and Thibault Collin Presynaptic NMDA receptors act as local high-gain glutamate detector in developing cerebellar molecular layer interneurons Journal of Neurochemistry 126
We wished to understand how presynaptic NMDA receptors (preNMDARs) are activated in cerebellar molecular layer interneurons (MLIs). We find that they can detect glutamate by mediating a calcium entry into the presynaptic termini, a signal that is further amplified by their ability to recruit ryanodine receptor. PreNMDARs can convert the glutamate released by volumic transmission into large presynaptic calcium transients.
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