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Bénédicte Rossi and Thibault Collin Presynaptic NMDA receptors act as local high-gain glutamate detector in developing cerebellar molecular layer interneurons Journal of Neurochemistry 126

Version of Record online: 15 MAY 2013 | DOI: 10.1111/jnc.12279

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We wished to understand how presynaptic NMDA receptors (preNMDARs) are activated in cerebellar molecular layer interneurons (MLIs). We find that they can detect glutamate by mediating a calcium entry into the presynaptic termini, a signal that is further amplified by their ability to recruit ryanodine receptor. PreNMDARs can convert the glutamate released by volumic transmission into large presynaptic calcium transients.

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