E-mail

E-mail a Wiley Online Library Link

Bénédicte Rossi and Thibault Collin Presynaptic NMDA receptors act as local high-gain glutamate detector in developing cerebellar molecular layer interneurons Journal of Neurochemistry 126

Article first published online: 15 MAY 2013 | DOI: 10.1111/jnc.12279

Thumbnail image of graphical abstract

We wished to understand how presynaptic NMDA receptors (preNMDARs) are activated in cerebellar molecular layer interneurons (MLIs). We find that they can detect glutamate by mediating a calcium entry into the presynaptic termini, a signal that is further amplified by their ability to recruit ryanodine receptor. PreNMDARs can convert the glutamate released by volumic transmission into large presynaptic calcium transients.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH