Sarah L. Cousins, Neal Innocent and F. Anne Stephenson Neto1 associates with the NMDA receptor/amyloid precursor protein complex Journal of Neurochemistry 126
Neto1 is shown to be a constituent of APP/NMDA receptor trafficking complexes. Since Neto1 is shown to associate with GluN2 expressed alone and, APP with GluN1-1a alone, it is proposed that trafficking complexes are formed in the endoplasmic reticulum and contribute to regulation of NMDA receptor surface expression. Alternative scenarios are depicted since it is to be determined if respective associations are direct.
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