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Franc Llorens, Patricia Carulla, Ana Villa, Juan M. Torres, Puri Fortes, Isidre Ferrer and José A. del Río PrPC regulates epidermal growth factor receptor function and cell shape dynamics in Neuro2a cells Journal of Neurochemistry 127

Version of Record online: 28 MAY 2013 | DOI: 10.1111/jnc.12283

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In this study, we analyzed the PrPC-dependent gene expression signature of neuroblastoma (N2a) cells after transient acute up-regulation and down-regulation of PrPC. We demonstrate that PrPC plays roles in proliferation and neuritogenesis through modulation of EGFR activity. This approach will give new insights into the molecular mechanisms by which PrPC regulates key cellular functions in cell physiology.

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