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Jason Arsenault, Enrico Ferrari, Dhevahi Niranjan, Sabine A. G. Cuijpers, Chunjing Gu, Yvonne Vallis, John O'Brien and Bazbek Davletov Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cells Journal of Neurochemistry 126

Version of Record online: 20 MAY 2013 | DOI: 10.1111/jnc.12284

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Botulinum neurotoxin is an excellent tool for causing prolonged blockade of secretion offering the possibility of targeted modulation of neuroendocrine functions. We now show the potential of our new protein stapling technique for combinatorial and on-demand assembly of the botulinum enzyme with growth factors and neuropeptides to retarget the botulinum activity into desired cell populations for biomedical applications.

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