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Daigo Homma, Setsuko Katoh, Hirofumi Tokuoka and Hiroshi Ichinose The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine hydroxylase level in the brain Journal of Neurochemistry 126

Version of Record online: 22 MAY 2013 | DOI: 10.1111/jnc.12287

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Tetrahydrobiopterin (BH4) is an essential cofactor of tyrosine hydroxylase (TH). We found that BH4 and dopa administration in infancy restored the loss of TH protein caused by BH4 deficiency and that the effects of these treatments are attenuated in young adulthood. These findings indicate that the post-natal augmentation of TH protein requires catecholamines and suggest that there is a critical period for the dopaminergic development.

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