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Tatsuhide Tanaka, Koichi Murakami, Yoshio Bando and Shigetaka Yoshida Minocycline reduces remyelination by suppressing ciliary neurotrophic factor expression after cuprizone-induced demyelination Journal of Neurochemistry 127

Version of Record online: 20 MAY 2013 | DOI: 10.1111/jnc.12289

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To examine the role of microglia in remyelination, mice were treated with minocycline after cuprizone-induced demyelination. Minocycline treatment reduced the number of oligodendrocytes and CNTF expression in the remyelination phase. In vitro, CNTF directly affected the differentiation of oligodendrocytic cells. These findings suggest that minocycline reduces remyelination by suppressing CNTF expression by microglia after cuprizone-induced demyelination.

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